SysTox2013 presentations are posted as links under "Programme".
(1) To evaluate how state-of-the-art systems biology tools are or can be used to elucidate toxic modes of action and provide realistic exposure and biological impact assessments.
(2) To establish a framework for interpreting and applying Systems Toxicology data that will inform risk assessment policy and regulation of chemicals.
Humans are exposed to thousands of potentially adverse stressors including chemicals from the environment, diet, drugs and consumer products. At present, animal studies and an empirical one-by-one approach are used to identify and characterize risks to human health.
New powerful and rapid systems-wide approaches using (epi)genomics, proteomics, metabolomics, molecular dosimetry, and computational biology are likely to change the focus of risk assessment from empirical animal study-based endpoints to modes of action and critical life stages.
A clearer link is needed between systems biology data and human risk assessment that will improve the way toxicological data are collected, interpreted, and applied.